Integration of systems biology with organs-on-chips to humanize therapeutic development

"Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell and intracellular signaling networks...

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Bibliographic Details
Main Authors: Clark, Amanda M., Wells, Alan, Edington, Collin D, Cirit, Murat, Chen, Wen Li, Trumper, David L, Griffith, Linda G
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Published: SPIE 2018
Online Access:http://hdl.handle.net/1721.1/115077
https://orcid.org/0000-0002-5248-871X
https://orcid.org/0000-0003-1137-0413
https://orcid.org/0000-0001-5358-5450
https://orcid.org/0000-0002-1801-5548