Palladium-Mediated Arylation of Lysine in Unprotected Peptides
A mild method for the arylation of lysine in an unprotected peptide is presented. In the presence of a preformed biarylphosphine-supported palladium(II)–aryl complex and a weak base, lysine amino groups underwent C−N bond formation at room temperature. The process generally exhibited high selectivit...
| Main Authors: | , , , |
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| Format: | Article |
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Wiley-Blackwell
2018
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| Online Access: | http://hdl.handle.net/1721.1/115190 https://orcid.org/0000-0001-8075-1100 https://orcid.org/0000-0003-4192-0658 https://orcid.org/0000-0003-3875-4775 |