PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

Alkylating agents are commonly used to treat cancer. Although base excision repair (BER) is a major pathway for repairing DNA alkylation damage, under certain conditions, the initiation of BER produces toxic repair intermediates that damage healthy tissues. The initiation of BER by the alkyladenine...

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Bibliographic Details
Main Authors: Allocca, Mariacarmela, Corrigan, Joshua, Fake, Kimberly, Samson, Leona D, Calvo, Jennifer A.
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Published: Impact Journals, LLC 2018
Online Access:http://hdl.handle.net/1721.1/115208
https://orcid.org/0000-0002-7112-1454

Internet

http://hdl.handle.net/1721.1/115208
https://orcid.org/0000-0002-7112-1454

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