Transcription factor family‐specific DNA shape readout revealed by quantitative specificity models

Transcription factor family‐specific DNA shape readout revealed by quantitative specificity models

Transcription factors (TFs) achieve DNA-binding specificity through contacts with functional groups of bases (base readout) and readout of structural properties of the double helix (shape readout). Currently, it remains unclear whether DNA shape readout is utilized by only a few selected TF families...

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Bibliographic Details
Main Authors: Yang, Lin, Orenstein, Yaron, Jolma, Arttu, Yin, Yimeng, Taipale, Jussi, Shamir, Ron, Rohs, Remo
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/115256
https://orcid.org/0000-0002-3583-3112

Internet

http://hdl.handle.net/1721.1/115256
https://orcid.org/0000-0002-3583-3112

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