Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

In the hepatitis B virus (HBV)-related hepatocellular carcinoma tumor microenvironment (TME), monocytes reportedly impede natural T cell functions via PD-L1/PD-1 signaling. However, it remains unclear if T cell receptor-redirected T cells (TCR T cells) are similarly inhibited. Hence, we developed a...

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Bibliographic Details
Main Authors: Lee, Sharon Wei Ling, Adriani, Giulia, Ceccarello, Erica, Pavesi, Andrea, Tan, Anthony Tanoto, Bertoletti, Antonio, Kamm, Roger Dale, Wong, Siew Cheng
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Frontiers Research Foundation 2018
Online Access:http://hdl.handle.net/1721.1/115345
https://orcid.org/0000-0002-7232-304X

Internet

http://hdl.handle.net/1721.1/115345
https://orcid.org/0000-0002-7232-304X

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