Optimized Sequence Library Design for Efficient In Vitro Interaction Mapping

Optimized Sequence Library Design for Efficient In Vitro Interaction Mapping

Sequence libraries that cover all k-mers enable universal, unbiased measurements of binding to both oligonucleotides and peptides. While the number of k-mers grows exponentially in k, space on all experimental platforms is limited. Here, we shrink k-mer library sizes by using joker characters, which...

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Bibliographic Details
Main Authors: Puccinelli, Robert, Kim, Ryan, Fordyce, Polly, Orenstein, Yaron, Berger Leighton, Bonnie
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/115384
https://orcid.org/0000-0002-3583-3112
https://orcid.org/0000-0002-2724-7228

Internet

http://hdl.handle.net/1721.1/115384
https://orcid.org/0000-0002-3583-3112
https://orcid.org/0000-0002-2724-7228

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