Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen- specific B cell proliferation, differentiation of B ce...

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Автори: Sanjuan Nandin, Irene, Fong, Carol, Deantonio, Cecilia, Torreno-Pina, Juan A., Pecetta, Simone, Maldonado, Paula, Gasparrini, Francesca, Kjaer, Svend, Borley, Daryl W., Nair, Usha, Coleman, Julia A., Lingwood, Daniel, Meffre, Eric, Poignard, Pascal, Burton, Dennis R., Batista, Facundo D., Ordovas-Montanes, Jose Manuel, Kazer, Samuel Weisgurt, Shalek, Alexander K
Інші автори: Institute for Medical Engineering and Science
Формат: Стаття
Опубліковано: Rockefeller University Press 2018
Онлайн доступ:http://hdl.handle.net/1721.1/115401
https://orcid.org/0000-0002-7380-9594
https://orcid.org/0000-0001-5670-8778