Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro mode...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
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MDPI AG
2018
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Online Access: | http://hdl.handle.net/1721.1/115860 https://orcid.org/0000-0002-5585-9280 https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-4255-0492 |