Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro mode...

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Bibliographic Details
Main Authors: van der Valk, Dewy C., Blaser, Mark C., Grolman, Joshua M., Wu, Pin-Jou, Lee, Lang H., Wen, Jennifer R., Ha, Anna H., Buffolo, Fabrizio, van Mil, Alain, Bouten, Carlijn V. C., Body, Simon C., Mooney, David J., Sluijter, Joost P. G., Aikawa, Masanori, Hjortnaes, Jesper, Aikawa, Elena, van der Valk, Dewy, van der Ven, Casper, Blaser, Mark, Grolman, Joshua, Fenton, Owen, Lee, Lang, Tibbitt, Mark, Andresen, Jason, Wen, Jennifer, Ha, Anna, Bouten, Carlijn, Body, Simon, Mooney, David, Sluijter, Joost, van der Ven, Casper F.t., Tibbitt, Mark W, Langer, Robert S, Fenton, Owen Shea
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Published: MDPI AG 2018
Online Access:http://hdl.handle.net/1721.1/115860
https://orcid.org/0000-0002-5585-9280
https://orcid.org/0000-0002-4917-7187
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/115860
https://orcid.org/0000-0002-5585-9280
https://orcid.org/0000-0002-4917-7187
https://orcid.org/0000-0003-4255-0492

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