Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PKM2 is also the pyruvate kinase isoform expressed in most wild-t...

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Bibliographic Details
Main Authors: Dayton, Talya L., Miller, Kathryn M., Bronson, Roderick T., Gocheva, Vasilena, Miller, Kathryn, Bhutkar, Arjun, Chidley, Caroline, Vander Heiden, Matthew G., Jacks, Tyler E.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: BioMed Central Ltd. 2018
Online Access:http://hdl.handle.net/1721.1/116108
https://orcid.org/0000-0002-7994-7963
https://orcid.org/0000-0002-7799-6454
https://orcid.org/0000-0002-6883-3805
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0001-5785-8911

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http://hdl.handle.net/1721.1/116108
https://orcid.org/0000-0002-7994-7963
https://orcid.org/0000-0002-7799-6454
https://orcid.org/0000-0002-6883-3805
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0001-5785-8911

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