Structural Basis of an N-Degron Adaptor with More Stringent Specificity

The N-end rule dictates that a protein's N-terminal residue determines its half-life. In bacteria, the ClpS adaptor mediates N-end-rule degradation, by recognizing proteins bearing specific N-terminal residues and delivering them to the ClpAP AAA+ protease. Unlike most bacterial clades, many α-...

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Bibliographic Details
Main Authors: Stein, Benjamin Joseph, Grant, Robert A., Sauer, Robert T., Baker, Tania
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116152
https://orcid.org/0000-0002-2246-2674
https://orcid.org/0000-0002-1719-5399