Single-chromosome Gains Commonly Function as Tumor Suppressors

Single-chromosome Gains Commonly Function as Tumor Suppressors

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as...

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Bibliographic Details
Main Authors: Chung, Erica S., Sayles, Nicole M., Passerini, Verena, Storchova, Zuzana, Sheltzer, Jason Meyer, Ko, Julie H., Replogle, John Michael, Habibe Burgos, Nicole C., Meehl, Colleen M., Amon, Angelika B.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116154
https://orcid.org/0000-0003-1381-1323
https://orcid.org/0000-0003-2735-8195

Internet

http://hdl.handle.net/1721.1/116154
https://orcid.org/0000-0003-1381-1323
https://orcid.org/0000-0003-2735-8195

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