Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination

Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination

The G protein-coupled GABAB receptors, constituted from GABAB1 and GABAB2 subunits, are important regulators of neuronal excitability by mediating long-lasting inhibition. One factor that determines receptor availability and thereby the strength of inhibition is regulated protein degradation. GABAB...

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Bibliographic Details
Main Authors: Zemoura, Khaled, Balakrishnan, Karthik, Grampp, Thomas, Benke, Dietmar
Other Authors: Picower Institute for Learning and Memory
Format: Article
Language:English
Published: Springer US 2018
Online Access:http://hdl.handle.net/1721.1/116293

Internet

http://hdl.handle.net/1721.1/116293

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