A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis

Oxetanocin A (OXT-A) is a potent antitumour, antiviral and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster that contains four genes: oxsA, oxsB, oxrA and oxrB. Here we show that both the oxsA and oxsB genes are required for the produc...

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Bibliographic Details
Main Authors: Zhong, Aoshu, Sun, He G., Liu, Hung-wen, Rabb, Jennifer, Drennan, Catherine L.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/116346
https://orcid.org/0000-0002-7437-6217
https://orcid.org/0000-0001-5486-2755