A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis
Oxetanocin A (OXT-A) is a potent antitumour, antiviral and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster that contains four genes: oxsA, oxsB, oxrA and oxrB. Here we show that both the oxsA and oxsB genes are required for the produc...
Main Authors: | Zhong, Aoshu, Sun, He G., Liu, Hung-wen, Rabb, Jennifer, Drennan, Catherine L. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Published: |
Springer Nature
2018
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Online Access: | http://hdl.handle.net/1721.1/116346 https://orcid.org/0000-0002-7437-6217 https://orcid.org/0000-0001-5486-2755 |
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