Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects

Defining the genes that are essential for cellular proliferation is critical for understanding organismal development and identifying high-value targets for disease therapies. However, the requirements for cell-cycle progression in human cells remain incompletely understood. To elucidate the consequ...

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Bibliographic Details
Main Authors: McKinley, Kara Lavidge, Cheeseman, Iain M
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116347
https://orcid.org/0000-0001-6283-9168
https://orcid.org/0000-0002-3829-5612