Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects
Defining the genes that are essential for cellular proliferation is critical for understanding organismal development and identifying high-value targets for disease therapies. However, the requirements for cell-cycle progression in human cells remain incompletely understood. To elucidate the consequ...
Main Authors: | McKinley, Kara Lavidge, Cheeseman, Iain M |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Published: |
Elsevier BV
2018
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Online Access: | http://hdl.handle.net/1721.1/116347 https://orcid.org/0000-0001-6283-9168 https://orcid.org/0000-0002-3829-5612 |
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