In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the need to generate and cross germline mutant mice. Here we describe approaches to model colorectal cancer (CRC) and metastasis, which rely on in situ gene editing and orthotopic organoid transplantation in mic...

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Main Authors:	Taylor, Martin S., Sicinska, Ewa T., Suarez, Yvelisse, Yoo, James, Chen, Lillian, Zukerberg, Lawrence, Katajisto, Pekka, Deshpande, Vikram, Bass, Adam J., Tsichlis, Philip N., Roper, Jatin, Tammela, Tuomas, Cetinbas, Naniye, Akkad, Adam, Roghanian, Ali, Rickelt, Steffen, Almeqdadi, Mohammad, Oberli, Matthias, Sanchez-Rivera, Francisco Javier, Park, Yoona K., Liang, Xu, Eng, George M., Azimi, Roxana S., Kedrin, Dmitriy, Neupane, Rachit, Beyaz, Semir, Lees, Jacqueline, Langer, Robert S., Hynes, Richard O., Chen, Jianzhu, Bhutkar, Arjun, Jacks, Tyler E., Yilmaz, Omer
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Published:	Nature Publishing Group 2018
Online Access:	http://hdl.handle.net/1721.1/116349 https://orcid.org/0000-0003-3675-6961 https://orcid.org/0000-0003-1316-4218 https://orcid.org/0000-0002-5224-7764 https://orcid.org/0000-0002-5503-2371 https://orcid.org/0000-0003-0272-9623 https://orcid.org/0000-0001-6093-7282 https://orcid.org/0000-0002-2598-0098 https://orcid.org/0000-0001-9451-2194 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0001-7603-8396 https://orcid.org/0000-0002-5687-6154 https://orcid.org/0000-0001-5785-8911 https://orcid.org/0000-0002-7577-4612

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In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

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