Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing

The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear. The origin-recognition complex (ORC), Cdc6 and Cdt1 facilitate this process by establishing a topological link betw...

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Bibliographic Details
Main Authors: Ticau, Simina, Friedman, Larry J, Champasa, Kanokwan, Corrêa, Ivan R, Gelles, Jeff, Bell, Stephen P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/116464
https://orcid.org/0000-0001-9500-7544
https://orcid.org/0000-0001-8265-4654
https://orcid.org/0000-0002-2876-610X