Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing
The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear. The origin-recognition complex (ORC), Cdc6 and Cdt1 facilitate this process by establishing a topological link betw...
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Springer Nature
2018
|
| Online Access: | http://hdl.handle.net/1721.1/116464 https://orcid.org/0000-0001-9500-7544 https://orcid.org/0000-0001-8265-4654 https://orcid.org/0000-0002-2876-610X |