Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

The ability of a cancer cell to migrate through the dense extracellular matrix within and surrounding the solid tumor is a critical determinant of metastasis. Macrophages enhance invasion and metastasis in the tumor microenvironment, but the basis for their effects is not fully understood. Using a m...

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Bibliographic Details
Main Authors: Hebert, Jess D., Boussommier-Calleja, Alexandra, Hynes, Richard O., Li, Ran, Lee, Tara A., Xing, Hao, Lauffenburger, Douglas A, Kamm, Roger Dale
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: American Association for Cancer Research (AACR) 2018
Online Access:http://hdl.handle.net/1721.1/116520
https://orcid.org/0000-0002-8537-8824
https://orcid.org/0000-0002-0050-989X
https://orcid.org/0000-0002-7232-304X

Internet

http://hdl.handle.net/1721.1/116520
https://orcid.org/0000-0002-8537-8824
https://orcid.org/0000-0002-0050-989X
https://orcid.org/0000-0002-7232-304X

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