Modeling Tumor Clonal Evolution for Drug Combinations Design

Modeling Tumor Clonal Evolution for Drug Combinations Design

Cancer is a clonal evolutionary process. This presents challenges for effective therapeutic intervention, given the constant selective pressure toward drug resistance. Mathematical modeling from population genetics, evolutionary dynamics, and engineering perspectives are being increasingly employed...

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Bibliographic Details
Main Authors: Zhao, Boyang, Hemann, Michael, Lauffenburger, Douglas A
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Published: Elsevier BV 2018
Subjects:
intratumoral heterogeneity tumor clonal evolution mathematical/computational modeling drug combinations drug resistance
Online Access:http://hdl.handle.net/1721.1/116546
https://orcid.org/0000-0003-4610-1707
https://orcid.org/0000-0002-0050-989X

Internet

http://hdl.handle.net/1721.1/116546
https://orcid.org/0000-0003-4610-1707
https://orcid.org/0000-0002-0050-989X

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