Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome evolution. Given the potential of cells with abnormal karyotypes to become cancero...

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Bibliographic Details
Main Authors: Richardson, Amelia, Iyer, Divya Ramalingam, Wong, Yao Liang, Rhind, Nicholas, Desai, Arshad, Santaguida, Stefano, M'Saad, Ons, Zasadil, Lauren M, Knouse, Kristin Ann, Amon, Angelika B
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116548
https://orcid.org/0000-0002-1501-6190
https://orcid.org/0000-0003-0649-7428
https://orcid.org/0000-0001-9837-0314

Internet

http://hdl.handle.net/1721.1/116548
https://orcid.org/0000-0002-1501-6190
https://orcid.org/0000-0003-0649-7428
https://orcid.org/0000-0001-9837-0314

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