Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied. We infused mice with lung cancers with isotope-labeled glucose or glutamine and compared the fate of the...

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Bibliographic Details
Main Authors: Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Jha, Abhishek K., Pierce, Kerry A., Mott, Bryan T., Clish, Clary B., Davidson, Shawn M., Luengo, Alba, Bauer, Matthew R., Keibler, Mark Andrew, O'Brien, James P., Gui, Dan Yi, Sullivan, Lucas Bryan, Wasylenko, Thomas Michael, Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Jacks, Tyler E., Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116557
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0002-6745-8222
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/116557
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0002-6745-8222
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-6702-4192

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