Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathways is unknown. Kras activation and Trp53 deletion...

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Bibliographic Details
Main Authors: Ji, B. W., Dixit, P. D., Wolpin, B. M., Vitkup, D., Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Hosios, Aaron Marc, Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler E., Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: American Association for the Advancement of Science (AAAS) 2018
Online Access:http://hdl.handle.net/1721.1/116559
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-8206-8003
https://orcid.org/0000-0001-9587-0233
https://orcid.org/0000-0003-4250-7355
https://orcid.org/0000-0002-7702-5877
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-6702-4192

Internet

http://hdl.handle.net/1721.1/116559
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-8206-8003
https://orcid.org/0000-0001-9587-0233
https://orcid.org/0000-0003-4250-7355
https://orcid.org/0000-0002-7702-5877
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-6702-4192

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