The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Expression of the MECOM (also known as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloid leukemia (AML) and is associated with poor clinical outcome. Here, through transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 over...

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Bibliographic Details
Main Authors: Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Zhang, Yi, Perkins, Archibald S, Shannon, Kevin, Puissant, Alexandre, Stegmaier, Kimberly, Fenouille, Nina, Ramos, Azucena, Hemann, Michael
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Springer Nature 2018
Online Access:http://hdl.handle.net/1721.1/116620
https://orcid.org/0000-0001-7168-8672

Internet

http://hdl.handle.net/1721.1/116620
https://orcid.org/0000-0001-7168-8672

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