Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats. Knockdown and overexpression studies in human tumor cells showed that the shel...

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Bibliographic Details
Main Authors: Sexton, Alec N., Regalado, Samuel G., Cost, Gregory J., O’Neil, Colleen M., Urnov, Fyodor D., Gregory, Philip D., Collins, Kathleen, Hockemeyer, Dirk, Lai, Christine S., Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Cold Spring Harbor Laboratory Press 2018
Online Access:http://hdl.handle.net/1721.1/116621

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http://hdl.handle.net/1721.1/116621

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