Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans
Lithium has been a mainstay for the treatment of bipolar disorder, yet the molecular mechanisms underlying its action remain enigmatic. Bisphosphate 3′-nucleotidase (BPNT-1) is a lithium-sensitive phosphatase that catalyzes the breakdown of cytosolic 3′-phosphoadenosine 5′-phosphate (PAP), a byprodu...
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/116649 https://orcid.org/0000-0002-6944-5177 https://orcid.org/0000-0002-4109-5152 |