Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
TDP-43 (encoded by the gene TARDBP) is an RNA binding protein central to the pathogenesis of amyotrophic lateral sclerosis (ALS). However, how TARDBP mutations trigger pathogenesis remains unknown. Here, we use novel mouse mutants carrying point mutations in endogenous Tardbp to dissect TDP-43 funct...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
EMBO Press
2018
|
| Online Access: | http://hdl.handle.net/1721.1/116666 https://orcid.org/0000-0001-5016-0756 |