Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

Using a diverse collection of small molecules generated from a variety of sources, we measured protein-binding activities of each individual compound against each of 100 diverse (sequence-unrelated) proteins using small-molecule microarrays. We also analyzed structural features, including complexity...

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Bibliographic Details
Main Authors: Clemons, P. A., Bodycombe, N. E., Carrinski, H. A., Wilson, J. A., Wagner, B. K., Schreiber, S. L., Shamji, Alykhan, Koehler, Angela Nicole
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Published: Proceedings of the National Academy of Sciences 2018
Online Access:http://hdl.handle.net/1721.1/116671
https://orcid.org/0000-0002-3772-8156

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