A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Host proteins are essential for HIV entry and replication and can be important nonviral therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified nearly a thousand candidate host factors, but there is little agreement among studies and few factors have been validated. He...

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Bibliographic Details
Main Authors: Park, Ryan J, Koundakjian, Dylan, Hultquist, Judd F, Lamothe-Molina, Pedro, Monel, Blandine, Schumann, Kathrin, Yu, Haiyan, Krupzcak, Kevin M, Garcia-Beltran, Wilfredo, Piechocka-Trocha, Alicja, Krogan, Nevan J, Marson, Alexander, Hacohen, Nir, Walker, Bruce D, Wang, Tim, Sabatini, David, Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116682
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

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http://hdl.handle.net/1721.1/116682
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

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