Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloi...

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Bibliographic Details
Main Authors: Yu, Haiyan, Hughes, Nicholas W., Kendirli, Arek, Klein, Klara, Lander, Eric S., Wang, Tim, Liu, Bingxu, Chen, Walter W., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116683
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/116683
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-1446-7256

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