Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloi...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/116683 https://orcid.org/0000-0002-4227-5163 https://orcid.org/0000-0002-7043-5013 https://orcid.org/0000-0002-1446-7256 |