A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Progressive kidney diseases are often associated with scarring of the kidney’s filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited fo...

Full description

Bibliographic Details
Main Authors: Zhou, Yiming, Castonguay, Philip, Clark, Abbe R., Dvela-Levitt, Moran, Kim, Sookyung, Sieber, Jonas, Wieder, Nicolas, Jung, Ji Yong, Andreeva, Svetlana, Reichardt, Jana, Dubois, Frank, Hoffmann, Sigrid C., Basgen, John M., Montesinos, Mónica S., Weins, Astrid, Johnson, Ashley C., Garrett, Michael R., Hopkins, Corey R., Sidhom, Eriene-Heidi I, Lander, Eric Steven, Greka, Anna
Other Authors: Institute for Medical Engineering and Science
Format: Article
Published: American Association for the Advancement of Science (AAAS) 2018
Online Access:http://hdl.handle.net/1721.1/116684
https://orcid.org/0000-0002-2658-9672

Internet

http://hdl.handle.net/1721.1/116684
https://orcid.org/0000-0002-2658-9672

Similar Items