RNF43 is frequently mutated in colorectal and endometrial cancers

RNF43 is frequently mutated in colorectal and endometrial cancers

We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with...

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Bibliographic Details
Main Authors: Giannakis, Marios, Hodis, Eran, Jasmine Mu, Xinmeng, Yamauchi, Mai, Rosenbluh, Joseph, Cibulskis, Kristian, Saksena, Gordon, Lawrence, Michael S, Qian, Zhi Rong, Nishihara, Reiko, Van Allen, Eliezer M, Hahn, William C, Gabriel, Stacey B, Getz, Gad, Ogino, Shuji, Fuchs, Charles S, Garraway, Levi A, Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116687

Internet

http://hdl.handle.net/1721.1/116687

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