Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands. Here we link metabolic dysregulation in human BTICs to a nexus between MYC and de novo purine synthesis, mediating glucose-sustained anabo...

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Bibliographic Details
Main Authors: Wang, Xiuxing, Yang, Kailin, Xie, Qi, Wu, Qiulian, Mack, Stephen C, Kim, Leo J Y, Prager, Briana C, Flavahan, William A, Liu, Xiaojing, Singer, Meromit, Hubert, Christopher G, Miller, Tyler E, Zhou, Wenchao, Huang, Zhi, Fang, Xiaoguang, Suvà, Mario L, Hwang, Tae Hyun, Locasale, Jason W, Bao, Shideng, Rich, Jeremy N, Regev, Aviv, Shi, Yu, Ph. D. Massachusetts Institute of Technology
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116732
https://orcid.org/0000-0001-8567-2049

Internet

http://hdl.handle.net/1721.1/116732
https://orcid.org/0000-0001-8567-2049

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