JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways

JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways

JAK2 V617F is a mutant-activated JAK2 kinase found in most polycythemia vera (PV) patients; it skews normal proliferation and differentiation of hematopoietic stem and progenitor cells and simulates aberrant expansion of erythroid progenitors. JAK2 V617F is known to activate some signaling pathways...

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Bibliographic Details
Main Authors: Shi, Jiahai, Yuan, Bingbing, Hu, Wenqian, Lodish, Harvey F
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116735
https://orcid.org/0000-0002-7029-7415

Internet

http://hdl.handle.net/1721.1/116735
https://orcid.org/0000-0002-7029-7415

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