Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation

Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differen...

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Bibliographic Details
Main Authors: Karwacz, Katarzyna, Miraldi, Emily R, Pokrovskii, Maria, Madi, Asaf, Yosef, Nir, Wortman, Ivo, Chen, Xi, Watters, Aaron, Carriero, Nicholas, Awasthi, Amit, Bonneau, Richard, Littman, Dan, Kuchroo, Vijay K, Regev, Aviv
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116739
https://orcid.org/0000-0001-8567-2049

Internet

http://hdl.handle.net/1721.1/116739
https://orcid.org/0000-0001-8567-2049

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