Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation
Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differen...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Nature Publishing Group
2018
|
| Online Access: | http://hdl.handle.net/1721.1/116739 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826192114791219200 |
|---|---|
| author | Karwacz, Katarzyna Miraldi, Emily R Pokrovskii, Maria Madi, Asaf Yosef, Nir Wortman, Ivo Chen, Xi Watters, Aaron Carriero, Nicholas Awasthi, Amit Bonneau, Richard Littman, Dan Kuchroo, Vijay K Regev, Aviv |
| author2 | Broad Institute of MIT and Harvard |
| author_facet | Broad Institute of MIT and Harvard Karwacz, Katarzyna Miraldi, Emily R Pokrovskii, Maria Madi, Asaf Yosef, Nir Wortman, Ivo Chen, Xi Watters, Aaron Carriero, Nicholas Awasthi, Amit Bonneau, Richard Littman, Dan Kuchroo, Vijay K Regev, Aviv |
| author_sort | Karwacz, Katarzyna |
| collection | MIT |
| description | Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation. |
| first_indexed | 2024-09-23T09:06:29Z |
| format | Article |
| id | mit-1721.1/116739 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T09:06:29Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1167392022-09-26T10:32:32Z Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation Karwacz, Katarzyna Miraldi, Emily R Pokrovskii, Maria Madi, Asaf Yosef, Nir Wortman, Ivo Chen, Xi Watters, Aaron Carriero, Nicholas Awasthi, Amit Bonneau, Richard Littman, Dan Kuchroo, Vijay K Regev, Aviv Broad Institute of MIT and Harvard Massachusetts Institute of Technology. Department of Biology Regev, Aviv Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and have critical roles in the control of autoimmunity and resolution of inflammation. We found that the transcription factors IRF1 and BATF were induced early on after treatment with IL-27 and were required for the differentiation and function of Tr1 cells in vitro and in vivo. Epigenetic and transcriptional analyses revealed that both transcription factors influenced chromatin accessibility and expression of the genes required for Tr1 cell function. IRF1 and BATF deficiencies uniquely altered the chromatin landscape, suggesting that these factors serve a pioneering function during Tr1 cell differentiation. National Cancer Institute (U.S.) (Grant P30-CA14051) 2018-07-02T20:19:15Z 2018-07-02T20:19:15Z 2017-02 2016-08 2018-07-02T19:35:27Z Article http://purl.org/eprint/type/JournalArticle 1529-2908 1529-2916 http://hdl.handle.net/1721.1/116739 Karwacz, Katarzyna et al. “Critical Role of IRF1 and BATF in Forming Chromatin Landscape During Type 1 Regulatory Cell Differentiation.” Nature Immunology 18, 4 (February 2017): 412–421 © 2017 Nature America Inc, part of Springer Nature https://orcid.org/0000-0001-8567-2049 http://dx.doi.org/10.1038/NI.3683 Nature Immunology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Karwacz, Katarzyna Miraldi, Emily R Pokrovskii, Maria Madi, Asaf Yosef, Nir Wortman, Ivo Chen, Xi Watters, Aaron Carriero, Nicholas Awasthi, Amit Bonneau, Richard Littman, Dan Kuchroo, Vijay K Regev, Aviv Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |
| title | Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |
| title_full | Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |
| title_fullStr | Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |
| title_full_unstemmed | Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |
| title_short | Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation |
| title_sort | critical role of irf1 and batf in forming chromatin landscape during type 1 regulatory cell differentiation |
| url | http://hdl.handle.net/1721.1/116739 https://orcid.org/0000-0001-8567-2049 |
| work_keys_str_mv | AT karwaczkatarzyna criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT miraldiemilyr criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT pokrovskiimaria criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT madiasaf criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT yosefnir criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT wortmanivo criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT chenxi criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT wattersaaron criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT carrieronicholas criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT awasthiamit criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT bonneaurichard criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT littmandan criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT kuchroovijayk criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation AT regevaviv criticalroleofirf1andbatfinformingchromatinlandscapeduringtype1regulatorycelldifferentiation |