Mouse ooplasm confers context-specific reprogramming capacity

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear trans...

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Bibliographic Details
Main Authors: Chan, Michelle M, Smith, Zachary D, Egli, Dieter, Regev, Aviv, Meissner, Alexander, Chan, Michelle Mei Wah
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116756
https://orcid.org/0000-0001-8567-2049