NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and...

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Bibliographic Details
Main Authors: Alvarez, Samantha W., Sviderskiy, Vladislav O., Terzi, Erdem M., Papagiannakopoulos, Thales, Moreira, Andre L., Adams, Sylvia, Birsoy, Kıvanç, Sabatini, David, Possemato, Richard
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116767
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0002-2401-0030

Internet

http://hdl.handle.net/1721.1/116767
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0002-2401-0030

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