NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/116767 https://orcid.org/0000-0002-1446-7256 https://orcid.org/0000-0002-2401-0030 |