Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the dark zone (DZ). Although selection of GC B cells is triggered by antigen-dependent signals delivered in the LZ, DZ proli...

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Bibliographic Details
Main Authors: Ersching, Jonatan, Efeyan, Alejo, Mesin, Luka, Jacobsen, Johanne T., Pasqual, Giulia, Grabiner, Brian C., Dominguez-Sola, David, Victora, Gabriel D., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116768
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/116768
https://orcid.org/0000-0002-1446-7256

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