KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are a key input to this system, and act through the Rag GTPases to promote...

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Bibliographic Details
Main Authors: Shen, Kuang, Petri, Sabrina, Abu-Remaileh, Monther, Frankel, Wayne N., Wolfson, Rachel Laura, Chantranupong, Lynne, Wyant, Gregory Andrew, Gu, Xin, Orozco Segrera, Jose, Condon, Kendall Janine, Kedir, Jibril Fetu, Scaria, Sonia M., Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116769
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-3393-6927
https://orcid.org/0000-0002-4364-5912
https://orcid.org/0000-0002-9515-8892
https://orcid.org/0000-0002-1565-9049
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/116769
https://orcid.org/0000-0002-9535-7664
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-3393-6927
https://orcid.org/0000-0002-4364-5912
https://orcid.org/0000-0002-9515-8892
https://orcid.org/0000-0002-1565-9049
https://orcid.org/0000-0002-1446-7256

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