KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are a key input to this system, and act through the Rag GTPases to promote...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/116769 https://orcid.org/0000-0002-9535-7664 https://orcid.org/0000-0001-9388-1633 https://orcid.org/0000-0003-4642-3706 https://orcid.org/0000-0002-3393-6927 https://orcid.org/0000-0002-4364-5912 https://orcid.org/0000-0002-9515-8892 https://orcid.org/0000-0002-1565-9049 https://orcid.org/0000-0002-1446-7256 |