Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling via c-Myc. Mule also regulates protein levels o...

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Bibliographic Details
Main Authors: Dominguez-Brauer, Carmen, Hao, Zhenyue, Elia, Andrew J., Fortin, Jérôme M., Nechanitzky, Robert, Brauer, Patrick M., Sheng, Yi, Chio, Iok In Christine, Haight, Jillian, Pollett, Aaron, Cairns, Robert, Tworzyanski, Leanne, Inoue, Satoshi, Reardon, Colin, Marques, Ana, Silvester, Jennifer, Cox, Maureen A., Wakeham, Andrew, van Es, Johan H., Clevers, Hans, Sato, Toshiro, Mak, Tak W., Mana, Miyeko, Yilmaz, Omer, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116770
https://orcid.org/0000-0002-5516-4008
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/116770
https://orcid.org/0000-0002-5516-4008
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256

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