Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
Rapamycin, an inhibitor of mTOR complex 1 (mTORC1), improves insulin sensitivity in acute studies in vitro and in vivo by disrupting a negative feedback loop mediated by S6 kinase. We find that rapamycin has a clear biphasic effect on insulin sensitivity in C2C12 myotubes, with enhanced responsivene...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
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Frontiers Research Foundation
2018
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| Online Access: | http://hdl.handle.net/1721.1/116773 https://orcid.org/0000-0002-0079-4467 https://orcid.org/0000-0002-1446-7256 |