Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physio...

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Bibliographic Details
Main Authors: Knockenhauer, Kevin E., Schwartz, Thomas U., Saxton, Robert Andrew, Chantranupong, Lynne, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116774
https://orcid.org/0000-0002-9376-3984
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-1446-7256