Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physio...
Main Authors: | Knockenhauer, Kevin E., Schwartz, Thomas U., Saxton, Robert Andrew, Chantranupong, Lynne, Sabatini, David |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Published: |
Nature Publishing Group
2018
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Online Access: | http://hdl.handle.net/1721.1/116774 https://orcid.org/0000-0002-9376-3984 https://orcid.org/0000-0001-9388-1633 https://orcid.org/0000-0002-1446-7256 |
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