ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Aberrant activation of the PI3K/mTOR pathway is a common feature of many cancers and an attractive target for therapy, but resistance inevitably evolves as is the case for any cancer cell-targeted therapy. In animal tumor models, chronic inhibition of PI3K/mTOR initially inhibits tumor growth, but o...

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Bibliographic Details
Main Authors: Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Mills, Gordon B., Brugge, Joan S., Thoreen, Carson C, Kang, Seong-Cheol, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: American Association for Cancer Research (AACR) 2018
Online Access:http://hdl.handle.net/1721.1/116784
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/116784
https://orcid.org/0000-0002-1446-7256

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