Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

Mitochondria house metabolic pathways that impact most aspects of cellular physiology. While metabolite profiling by mass spectrometry is widely applied at the whole-cell level, it is not routinely possible to measure the concentrations of small molecules in mammalian organelles. We describe a metho...

Full description

Bibliographic Details
Main Authors: Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116785
https://orcid.org/0000-0002-7043-5013
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256